Treatment Of Sleeping Symptoms And Symptoms Of Parkinson...

Treatment of Sleeping 1 Disorders Should Be Considered in 2 Clinical Management of Parkinson’s Disease 3 4 5 Altair B. dos Santos1, George E. Barreto, PhD2, Kristi A. Kohlmeier, PhD3 * 6 7 1Department of Biological Sciences, Universidade Estadual do Sudoeste da Bahia, 8 Brazil. 9 2Departmento de Nutricià ³n y Bioquà ­mica, Facultad de Ciencias, Pontificia Universidad 10 Javeriana, Bogotà ¡ D.C., Colombia. 11 3Faculty of Health and Medical Sciences, Department of Drug Design and 12 Pharmacology, University of Copenhagen, Denmark. 13 14 15 Following two decades of research after the first clinical reports that sleep disturbances 16 can precede signs and motor symptoms of Parkinson s disease (PD), studies performed 17 examining sleep at the†¦show more content†¦Nor is it standard practice to suggest 31 prophylactic approaches in these patients to curb onset of PD. Clinical acceptance of 32 the link between sleeping disorders and later life onset of PD could be gained from 33 longitudinal studies with human patients focused on elucidating whether there exists a 34 strong association and/or causality between sleeping disorders and PD. However, this 35 approach raises ethical issues, especially if, in an attempt to provide compelling 36 evidence for causality, preventative interventions are given to one group of subjects and 37 not another. Nevertheless, at this time, improved monitoring and documentation of the 38 neurological progress of patients with sleeping disorders should be combined with 39 imaging studies in order to better characterize changes in neural regions controlling 40 sleep which occur in patients eventually presenting with PD. Animal models of PD, 41 which have contributed to provided compelling evidence that there is a link between 42 sleep and PD, should continue to be exploited to provide further